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NCAA1 League Games/Schedule (2021-2022)
| USC Upstate Games/Schedule | |||||||
| Regular Season | |||||||
| Nov. 9, 2021 | Day 1 | USC Upstate - S.Carolina | 60-78  | ||||
| Nov. 12, 2021 | Day 4 | USC Upstate - Charlotte | 64-76 | ||||
| Nov. 15, 2021 | Day 7 | St.Andrews - USC Upstate | 43-96  | ||||
| Nov. 18, 2021 | Day 10 | USC Upstate - ETSU | 43-56 | ||||
| Nov. 23, 2021 | Day 14 | USC Upstate - SC State | 82-78 | ||||
| Nov. 27, 2021 | Day 19 | Furman - USC Upstate | 87-77 | ||||
| Dec. 1, 2021 | Day 23 | NCCU - USC Upstate | 67-65 | ||||
| Dec. 4, 2021 | Day 26 | WCU - USC Upstate | 78-73 | ||||
| Dec. 11, 2021 | Day 33 | USC Upstate - Wake Forest | 53-79 | ||||
| Dec. 14, 2021 | Day 36 | USC Upstate - Tennessee (9) | 52-96 | ||||
| Dec. 18, 2021 | Day 40 | Converse - USC Upstate | 38-78 | ||||
| Dec. 21, 2021 | Day 44 | USC Upstate - Ohio | 70-85 | ||||
| Jan. 6, 2022 | Day 55 | Radford - USC Upstate | 82-77 | ||||
| Jan. 8, 2022 | Day 57 | USC Upstate - Presbyterian | 82-72 | ||||
| Jan. 12, 2022 | Day 61 | High Point - USC Upstate | 65-66 | ||||
| Jan. 15, 2022 | Day 64 | USC Upstate - UNC Asheville | 76-73 | ||||
| Jan. 19, 2022 | Day 68 | USC Upstate - Gardner-Webb | 74-61 | ||||
| Jan. 22, 2022 | Day 71 | Charleston So. - USC Upstate | 57-70 | ||||
| Jan. 26, 2022 | Day 75 | Winthrop - USC Upstate | 95-91 | ||||
| Jan. 29, 2022 | Day 78 | USC Upstate - NC A&T | 84-64 | ||||
| Feb. 2, 2022 | Day 82 | USC Upstate - Hampton | 85-78 | ||||
| Feb. 5, 2022 | Day 85 | Campbell - USC Upstate | 80-71 | ||||
| Feb. 10, 2022 | Day 90 | USC Upstate - Longwood | 72-85 | ||||
| Feb. 12, 2022 | Day 92 | UNC Asheville - USC Upstate | 83-56 | ||||
| Feb. 16, 2022 | Day 96 | Presbyterian - USC Upstate | 55-60 | ||||
| Feb. 19, 2022 | Day 99 | USC Upstate - Charleston So. | 78-73 | ||||
| Feb. 24, 2022 | Day 104 | USC Upstate - Winthrop | 59-89 | ||||
| Feb. 26, 2022 | Day 106 | Gardner-Webb - USC Upstate | 70-72 | ||||
| Mar. 4, 2022 | Day 112 | Charleston So. - USC Upstate | 62-72 | ||||
| Mar. 5, 2022 | Day 113 | USC Upstate - Longwood | 70-79 | ||||
| National Tournament Day 1 | |||||||
| Mar. 15, 2022 | Day 122 | USC Upstate - App State | 80-74 | ||||
| National Tournament Day 3 | |||||||
| Mar. 21, 2022 | Day 124 | USC Upstate - USA | 79-83 | ||||
NAIA Games/Schedule (2021-2022)
| USC Upstate Games/Schedule | |||||||
| Regular Season | |||||||
| Nov. 15, 2021 | Day 33 | St.Andrews - USC Upstate | 43-96 | ||||
NCAA2 Games/Schedule (2021-2022)
| USC Upstate Games/Schedule | |||||||
| Regular Season | |||||||
| Dec. 18, 2021 | Day 60 | Converse - USC Upstate | 38-78 | ||||
