| St.Francis, IN Games/Schedule |
| Regular Season |
| Oct. 27, 2021 | Day 14 | UM-Dearborn - St.Francis, IN (16) | 58-117  |
| Oct. 29, 2021 | Day 16 | Aquinas Coll. - St.Francis, IN (16) | 85-70  |
| Oct. 29, 2021 | Day 16 | Graceland - St.Francis, IN (16) | 69-89 |
| Oct. 30, 2021 | Day 17 | St.Francis, IN (16) - Aquinas Coll. | 80-63 |
| Nov. 3, 2021 | Day 21 | Indiana Tech (25) - St.Francis, IN (16) | 78-84 |
| Nov. 5, 2021 | Day 23 | St.Francis, IN (16) - Trinity Christian | 122-81 |
| Nov. 9, 2021 | Day 27 | St.Francis, IN (16) - Great Lakes Chr. | 95-90 |
| Nov. 12, 2021 | Day 30 | Rochester, MI - St.Francis, IN (16) | 59-69 |
| Nov. 20, 2021 | Day 38 | St.Francis, IN (16) - Goshen | 90-83 |
| Nov. 23, 2021 | Day 41 | MVNU - St.Francis, IN (16) | 61-94 |
| Dec. 1, 2021 | Day 48 | St.Francis, IN (16) - Grace | 69-83 |
| Dec. 4, 2021 | Day 51 | IWU (7) - St.Francis, IN (16) | 100-89 |
| Dec. 10, 2021 | Day 57 | St.Francis, IN (16) - Warner | 66-84 |
| Dec. 11, 2021 | Day 58 | St.Francis, IN (16) - Southeastern (18) | 72-74 |
| Dec. 28, 2021 | Day 71 | Holy Cross Coll. - St.Francis, IN (16) | 52-77 |
| Dec. 29, 2021 | Day 72 | ONU - St.Francis, IN (16) | 84-89 |
| Jan. 4, 2022 | Day 78 | Huntington - St.Francis, IN (16) | 87-97 |
| Jan. 8, 2022 | Day 82 | St.Francis, IN (16) - Spring Arbor | 95-58 |
| Jan. 11, 2022 | Day 85 | Marian, IN (12) - St.Francis, IN (16) | 63-70 |
| Jan. 15, 2022 | Day 89 | St.Francis, IN (16) - Taylor | 70-54 |
| Jan. 18, 2022 | Day 92 | Bethel, IN - St.Francis, IN (16) | 75-90 |
| Jan. 22, 2022 | Day 96 | Goshen - St.Francis, IN (16) | 64-76 |
| Jan. 25, 2022 | Day 99 | St.Francis, IN (16) - MVNU | 99-79 |
| Jan. 29, 2022 | Day 103 | St.Francis, IN (16) - IWU (7) | 79-87 |
| Feb. 1, 2022 | Day 106 | Grace - St.Francis, IN (16) | 73-86 |
| Feb. 5, 2022 | Day 110 | St.Francis, IN (16) - Huntington | 74-88 |
| Feb. 8, 2022 | Day 113 | St.Francis, IN (16) - Marian, IN (12) | 70-101 |
| Feb. 12, 2022 | Day 117 | Spring Arbor - St.Francis, IN (16) | 61-66 |
| Feb. 15, 2022 | Day 120 | St.Francis, IN (16) - Bethel, IN | 90-86 |
| Feb. 19, 2022 | Day 124 | Taylor - St.Francis, IN (16) | 67-71 |
| Feb. 23, 2022 | Day 128 | Huntington - St.Francis, IN (16) | 80-74 |
| National Tournament Day 1 |
| Mar. 11, 2022 | Day 136 | Northwestern, IA - St.Francis, IN (16) | 85-91 |
| National Tournament Day 2 |
| Mar. 12, 2022 | Day 137 | Bethel, KS (20) - St.Francis, IN (16) | 78-66 |
