| Louisville Games/Schedule |
| Regular Season |
| Nov. 10, 2017 | Round 1 | SE Missouri St. - Louisville (4) | 40-80 |
| Nov. 12, 2017 | Round 3 | Louisville (4) - Ohio St. (13) | 95-90 |
| Nov. 14, 2017 | Round 5 | Toledo - Louisville (4) | 55-90 |
| Nov. 16, 2017 | Round 7 | Michigan - Louisville (4) | 49-74 |
| Nov. 19, 2017 | Round 10 | Oregon (6) - Louisville (4) | 61-74 |
| Nov. 24, 2017 | Round 15 | Murray St. - Louisville (4) | 51-115 |
| Nov. 30, 2017 | Round 21 | Louisville (4) - Indiana | 72-59 |
| Dec. 3, 2017 | Round 24 | Louisville (4) - S.Dakota St. | 68-64 |
| Dec. 5, 2017 | Round 26 | Tenn-Martin - Louisville (4) | 56-91 |
| Dec. 7, 2017 | Round 28 | Vanderbilt - Louisville (4) | 57-79 |
| Dec. 9, 2017 | Round 30 | Middle Tenn.St. - Louisville (4) | 26-80 |
| Dec. 12, 2017 | Round 33 | Tennessee St. - Louisville (4) | 56-95 |
| Dec. 17, 2017 | Round 38 | Louisville (4) - Kentucky | 87-63 |
| Dec. 20, 2017 | Round 41 | Louisville (4) - Air Force | 62-50 |
| Dec. 28, 2017 | Round 49 | Louisville (4) - Georgia Tech | 74-71 |
| Dec. 31, 2017 | Round 52 | Louisville (4) - N.Carolina St. (21) | 55-47 |
| Jan. 4, 2018 | Round 56 | Duke (18) - Louisville (4) | 60-66 |
| Jan. 7, 2018 | Round 59 | Virginia Tech - Louisville (4) | 56-67 |
| Jan. 11, 2018 | Round 63 | Notre Dame (5) - Louisville (4) | 67-100 |
| Jan. 18, 2018 | Round 70 | Louisville (4) - Pittsburgh | 77-51 |
| Jan. 21, 2018 | Round 73 | Florida St. (11) - Louisville (4) | 50-49 |
| Jan. 25, 2018 | Round 77 | Louisville (4) - Miami, FL | 84-74 |
| Jan. 28, 2018 | Round 80 | Wake Forest - Louisville (4) | 52-89 |
| Feb. 1, 2018 | Round 84 | Louisville (4) - Virginia | 77-41 |
| Feb. 4, 2018 | Round 87 | Louisville (4) - Syracuse | 84-77 |
| Feb. 7, 2018 | Round 90 | Clemson - Louisville (4) | 46-65 |
| Feb. 12, 2018 | Round 95 | Louisville (4) - Connecticut (1) | 58-69 |
| Feb. 15, 2018 | Round 98 | Louisville (4) - Boston Coll. | 87-52 |
| Feb. 18, 2018 | Round 101 | Louisville (4) - N.Carolina | 67-57 |
| Feb. 22, 2018 | Round 105 | Virginia - Louisville (4) | 39-51 |
| Feb. 25, 2018 | Round 108 | Pittsburgh - Louisville (4) | 49-81 |
| Mar. 2, 2018 | Round 113 | Virginia Tech - Louisville (4) | 70-73 |
| Mar. 3, 2018 | Round 114 | N.Carolina St. (21) - Louisville (4) | 59-64 |
| Mar. 4, 2018 | Round 115 | Notre Dame (5) - Louisville (4) | 72-74 |
| National Tournament Round 2 |
| Mar. 18, 2018 | Round 124 | Marquette - Louisville (4) | 72-90 |
| Regional Semifinals |
| Mar. 23, 2018 | Round 125 | Stanford (16) - Louisville (4) | 59-86 |
| Regional Finals |
| Mar. 25, 2018 | Round 126 | Oregon St. (10) - Louisville (4) | 43-76 |
| Final Four |
| Mar. 30, 2018 | Round 127 | Louisville (4) - Mississippi St. (2) | 63-73 |
