| Louisville Games/Schedule |
| Regular Season |
| Nov. 3, 2025 | Day 1 | SC State - Louisville (19) | 45-104  |
| Nov. 6, 2025 | Day 4 | Jackson St. - Louisville (19) | 70-106 |
| Nov. 11, 2025 | Day 9 | Kentucky - Louisville (19) | 88-96 |
| Nov. 15, 2025 | Day 13 | Ohio - Louisville (19) | 81-106 |
| Nov. 21, 2025 | Day 19 | Louisville (19) - Cincinnati | 74-64 |
| Nov. 24, 2025 | Day 22 | EMU - Louisville (19) | 46-87 |
| Nov. 26, 2025 | Day 24 | NJIT - Louisville (19) | 47-104 |
| Dec. 3, 2025 | Day 31 | Louisville (19) - Arkansas (16) | 80-89  |
| Dec. 6, 2025 | Day 34 | Indiana - Louisville (19) | 78-87 |
| Dec. 13, 2025 | Day 41 | Memphis - Louisville (19) | 73-99 |
| Dec. 16, 2025 | Day 44 | Louisville (19) - Tennessee (23) | 62-83 |
| Dec. 20, 2025 | Day 48 | Montana - Louisville (19) | 54-94 |
| Dec. 30, 2025 | Day 55 | Louisville (19) - California | 90-70 |
| Jan. 2, 2026 | Day 58 | Louisville (19) - Stanford | 76-80 |
| Jan. 6, 2026 | Day 62 | Duke (6) - Louisville (19) | 84-73 |
| Jan. 10, 2026 | Day 66 | Boston Coll. - Louisville (19) | 62-75 |
| Jan. 13, 2026 | Day 69 | Virginia (15) - Louisville (19) | 79-70 |
| Jan. 17, 2026 | Day 73 | Louisville (19) - Pittsburgh | 100-59 |
| Jan. 24, 2026 | Day 80 | Virginia Tech - Louisville (19) | 71-85 |
| Jan. 26, 2026 | Day 82 | Louisville (19) - Duke (6) | 52-83 |
| Jan. 31, 2026 | Day 87 | SMU - Louisville (19) | 74-88 |
| Feb. 4, 2026 | Day 91 | Notre Dame - Louisville (19) | 65-76 |
| Feb. 7, 2026 | Day 94 | Louisville (19) - Wake Forest | 88-80 |
| Feb. 9, 2026 | Day 96 | NC State - Louisville (19) | 77-118 |
| Feb. 14, 2026 | Day 101 | Louisville (19) - Baylor | 82-71 |
| Feb. 17, 2026 | Day 104 | Louisville (19) - SMU | 85-95 |
| Feb. 21, 2026 | Day 108 | Georgia Tech - Louisville (19) | 70-87 |
| Feb. 23, 2026 | Day 110 | Louisville (19) - UNC (13) | 74-77 |
| Feb. 28, 2026 | Day 115 | Louisville (19) - Clemson (21) | 75-80 |
| Mar. 3, 2026 | Day 118 | Syracuse - Louisville (19) | 62-77 |
| Mar. 7, 2026 | Day 122 | Louisville (19) - Miami, FL | 92-89 |
| Mar. 12, 2026 | Day 123 | Louisville (19) - Miami, FL | 73-78 |
| Mar. 11, 2026 | Day 123 | SMU - Louisville (19) | 58-62 |
| National Tournament Day 1 |
| Mar. 19, 2026 | Day 1 | S.Florida - Louisville (19) | 79-83 |
| National Tournament Day 2 |
| Mar. 21, 2026 | Day 1 | Louisville (19) - Michigan St. (11) | 69-77 |
