| Rochester, MI Games/Schedule |
| Regular Season |
| Nov. 4, 2021 | Day 22 | MSU-Northern - Rochester, MI | 69-73  |
| Nov. 10, 2021 | Day 28 | Rochester, MI - UM-Dearborn | 77-47 |
| Nov. 12, 2021 | Day 30 | Rochester, MI - St.Francis, IN (16) | 59-69  |
| Nov. 13, 2021 | Day 31 | Rochester, MI - Rio Grande | 65-56 |
| Nov. 17, 2021 | Day 35 | Rochester, MI - UNOH | 70-56 |
| Nov. 20, 2021 | Day 38 | Indiana Tech (25) - Rochester, MI | 61-57 |
| Nov. 23, 2021 | Day 41 | Rochester, MI - Lawrence Tech | 63-72 |
| Dec. 4, 2021 | Day 51 | Rochester, MI - Cornerstone | 62-68 |
| Dec. 8, 2021 | Day 55 | IWU (7) - Rochester, MI | 51-78 |
| Dec. 11, 2021 | Day 58 | Rochester, MI - Madonna | 97-87 |
| Dec. 17, 2021 | Day 64 | CMU - Rochester, MI | 54-72 |
| Dec. 18, 2021 | Day 65 | Rochester, MI - Graceland | 88-58 |
| Dec. 20, 2021 | Day 67 | Rochester, MI - IWU (7) | 53-82 |
| Dec. 21, 2021 | Day 68 | CUNE (23) - Rochester, MI | 71-64 |
| Jan. 3, 2022 | Day 76 | East-West - Rochester, MI | 69-92 |
| Jan. 4, 2022 | Day 78 | East-West - Rochester, MI | 55-65 |
| Jan. 6, 2022 | Day 79 | Rochester, MI - Aquinas Coll. | 65-61 |
| Jan. 6, 2022 | Day 80 | Aquinas Coll. - Rochester, MI | 61-65 |
| Jan. 8, 2022 | Day 82 | Rochester, MI - Concordia, MI | 77-56 |
| Jan. 15, 2022 | Day 89 | Rochester, MI - Lourdes | 69-77 |
| Jan. 19, 2022 | Day 93 | UM-Dearborn - Rochester, MI | 63-69 |
| Jan. 22, 2022 | Day 96 | Rochester, MI - SHU | 78-62 |
| Jan. 24, 2022 | Day 98 | Lourdes - Rochester, MI | 65-64 |
| Jan. 26, 2022 | Day 100 | Lawrence Tech - Rochester, MI | 54-79 |
| Jan. 29, 2022 | Day 103 | Rochester, MI - Indiana Tech (25) | 53-69 |
| Feb. 2, 2022 | Day 107 | UNOH - Rochester, MI | 63-86 |
| Feb. 5, 2022 | Day 110 | Cornerstone - Rochester, MI | 69-67 |
| Feb. 12, 2022 | Day 117 | Concordia, MI - Rochester, MI | 39-71 |
| Feb. 16, 2022 | Day 121 | Rochester, MI - Aquinas Coll. | 71-81 |
| Feb. 19, 2022 | Day 124 | Madonna - Rochester, MI | 57-67 |
| Feb. 23, 2022 | Day 128 | Rochester, MI - Lourdes | 59-79 |
