| Loyola, LA Games/Schedule |
| Regular Season |
| Oct. 23, 2021 | Day 10 | North American - Loyola, LA (2) | 56-134  |
| Oct. 26, 2021 | Day 13 | Loyola, LA (2) - Xavier, LA | 67-58 |
| Oct. 28, 2021 | Day 15 | Loyola, LA (2) - Dillard | 85-74 |
| Nov. 4, 2021 | Day 22 | LSUS (21) - Loyola, LA (2) | 79-87 |
| Nov. 16, 2021 | Day 34 | Loyola, LA (2) - Spring Hill | 91-66 |
| Nov. 18, 2021 | Day 36 | Loyola, LA (2) - MGA | 91-60 |
| Nov. 20, 2021 | Day 38 | Loyola, LA (2) - Brewton Parker | 78-40 |
| Nov. 22, 2021 | Day 40 | Baptist Bible, MO - Loyola, LA (2) | 75-108 |
| Nov. 23, 2021 | Day 41 | Loyola, LA (2) - LSUA | 102-81 |
| Nov. 24, 2021 | Day 42 | USAO (10) - Loyola, LA (2) | 64-81 |
| Nov. 30, 2021 | Day 47 | Dillard - Loyola, LA (2) | 62-95 |
| Dec. 2, 2021 | Day 49 | Loyola, LA (2) - William Carey | 78-71 |
| Dec. 9, 2021 | Day 56 | Loyola, LA (2) - LSUS (21) | 76-69 |
| Jan. 2, 2022 | Day 76 | UFTL - Loyola, LA (2) | 68-86 |
| Jan. 3, 2022 | Day 77 | Mobile, AL - Loyola, LA (2) | 75-77 |
| Jan. 6, 2022 | Day 80 | Loyola, LA (2) - Dalton St. | 85-57 |
| Jan. 17, 2022 | Day 91 | Loyola, LA (2) - Faulkner (15) | 73-92  |
| Jan. 22, 2022 | Day 96 | William Carey - Loyola, LA (2) | 64-91 |
| Jan. 27, 2022 | Day 101 | MGA - Loyola, LA (2) | 76-129 |
| Jan. 29, 2022 | Day 103 | Brewton Parker - Loyola, LA (2) | 69-114 |
| Feb. 3, 2022 | Day 108 | Loyola, LA (2) - Mobile, AL | 71-58 |
| Feb. 5, 2022 | Day 110 | Faulkner (15) - Loyola, LA (2) | 69-121 |
| Feb. 8, 2022 | Day 113 | BMC - Loyola, LA (2) | 58-100 |
| Feb. 10, 2022 | Day 115 | Dalton St. - Loyola, LA (2) | 80-91 |
| Feb. 12, 2022 | Day 117 | Talladega (6) - Loyola, LA (2) | 82-90 |
| Feb. 14, 2022 | Day 119 | Stillman - Loyola, LA (2) | 83-90 |
| Feb. 17, 2022 | Day 122 | Loyola, LA (2) - Stillman | 81-80 |
| Feb. 19, 2022 | Day 124 | Loyola, LA (2) - BMC | 90-76 |
| Feb. 20, 2022 | Day 125 | Loyola, LA (2) - Talladega (6) | 77-71 |
| Feb. 24, 2022 | Day 129 | William Carey - Loyola, LA (2) | 59-78 |
| Feb. 25, 2022 | Day 130 | Stillman - Loyola, LA (2) | 69-82 |
| Feb. 26, 2022 | Day 131 | Talladega (6) - Loyola, LA (2) | 63-73 |
| National Tournament Day 1 |
| Mar. 11, 2022 | Day 136 | BENUM - Loyola, LA (2) | 82-119 |
| 1/8 Finals |
| Mar. 17, 2022 | Day 138 | Faulkner (15) - Loyola, LA (2) | 67-85 |
| National Tournament Day 2 |
| Mar. 12, 2022 | Day 137 | Florida Coll. - Loyola, LA (2) | 75-106 |
| Quarter-Finals |
| Mar. 19, 2022 | Day 139 | Idaho Coll. (9) - Loyola, LA (2) | 53-60 |
| Semifinals |
| Mar. 21, 2022 | Day 140 | ACU (4) - Loyola, LA (2) | 70-82 |
| Finals |
| Mar. 22, 2022 | Day 141 | Talladega (6) - Loyola, LA (2) | 56-71 |
